Job Description

Associate Director, Computational Chemistry

Company: Takeda

Location: Cambridge, MA (hybrid, per Takedas Hybrid and Remote Work policy)

Objective / Purpose

• As a Senior Computational Chemistry Leader, work as part of a multidisciplinary team of Medicinal Chemists, Computational Chemists, Data Scientists, Structural Biologists, Pharmacologists and Biologists to provide Computational expertise to advance drug discovery projects.
• This role supports small molecule research initiatives across Takeda research sites, leading computational chemistry efforts to drive project progression at both locations.
• Implement and execute innovative computational methodologies and tools such as AI, free energy, and cheminformatics approaches to support drug discovery efforts.

Accountabilities

• Demonstrate expert understanding of computational chemistry principles and their application within a multidisciplinary drug discovery environment.
• Identify, develop, validate, and implement innovative computational approaches that improve research productivity and success.
• Provide crucial technical knowledge and input to project teams to drive decisionmaking in drug discovery projects.
• Build and develop a strong team of Computational Chemists to high productivity levels.

Education & Competencies

• Expertise in a variety of computational tools and methodologies including docking, virtual screening, molecular dynamics, free energy perturbation, homology modeling, quantum mechanics, pharmacophore elucidation, data mining, machine learning, cheminformatics, clustering, similarity & diversity analysis.
• Significant industry experience contributing as Computational Chemist on drug discovery projects.
• Strong impact in progressing discovery projects from hits to clinical leads.
• Extensive knowledge & experience in using a variety of tools for Hit ID.
• Provide project teams with computational strategies to inform, influence, and prioritize compound designs for potency/selectivity and improve ADME/Tox endpoints.
• Ability to effectively integrate emerging generative chemistry methods and other modern machine learning and AI applications in small molecule drug discovery.
• Proficiency with stateoftheart computational chemistry software.

Leadership

• Identifies, plans and executes novel scientific projects and leads platform initiatives.
• Experience in a supervisory role is strongly preferred.

Educational, Behavioral Competencies and Skills

• PhD degree in a scientific discipline with 7+ years of industry (pharma/biotech) drug discovery experience required.

Compensation and Benefits Summary

Location: Boston, MA
U.S. Base Salary Range: $153,600.00 $241,340.00
The estimated salary range reflects an anticipated range for this position. The actual base salary offered may depend on a variety of factors, including the qualifications of the individual applicant for the position, years of relevant experience, specific and unique skills, level of education attained, certifications or other professional licenses held, and the location in which the applicant lives and/or from which they will be performing the job. The actual base salary offered will be in accordance with state or local minimum wage requirements for the job location.

U.S. based employees may be eligible for shortterm and/or longterm incentives. They may also participate in medical, dental, vision insurance, a 401(k) plan and company match, shortterm and longterm disability coverage, basic life insurance, a tuition reimbursement program, paid volunteer time off, company holidays, and wellbeing benefits, among others. U.S. based employees are also eligible to receive, per calendar year, up to 80 hours of sick time, and new hires are eligible to accrue up to 120 hours of paid vacation.

EEO Statement

Takeda is proud in its commitment to creating a diverse workforce and providing equal employment opportunities to all employees and applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, gender expression, parental status, national origin, age, disability, citizenship status, genetic information or characteristics, marital status, status as a Vietnam era veteran, special disabled veteran, or other protected veteran in accordance with applicable federal, state and local laws, and any other characteristic protected by law.

It is unlawful in Massachusetts to require or administer a lie detector test as a condition of employment or continued employment. An employer who violates this law shall be subject to criminal penalties and civil liability.

Worker Type: Employee
Worker SubType: Regular
Time Type: Full time
Job Exempt: Yes

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Job Tags

Minimum wage, Full time, Local area, Remote work,

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